Compound 919278 ( —— )

Catalog No. M13493 CAS No. 2189366-77-4

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Compound 919278
Note

Research use only, not for human use.
Brief Description

Compound 919278 is a specific inhibitor of lymphotoxin β receptor (LTβR, IC50=0.169 uM).
Description

Compound 919278 is a specific inhibitor of lymphotoxin β receptor (LTβR, IC50=0.169 uM), and TNF receptor superfamily member 12A (FN14)-dependent nuclear translocation of p52 (IC50=0.167 uM) via inhibiting CDK12/CCNK, does not inhibit the TNF-α-mediated nuclear translocation of p65 (RelA); prevents the accumulation of NIK, selectively inhibits the noncanonical NF-kB pathway; prevents the LTβR- and FN14-dependent expression of MAP3K14 (which encodes NIK) as well as NIK accumulation by reducing phosphorylation of the carboxyl-terminal domain of RNA polymerase II; reduces the binding of both CDK12 and its associated protein CCNK with IC50 of 30-60 nM, inhibits CDK12 cellular activity and reduces the phosphorylation of Ser2 on the RNA Pol II CTD; phenocopies the effect of CDK12 knockdown on DEGs.
Synonyms

——
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

——
Indication

——

CAS Number

2189366-77-4
Formula Weight

320.35
Molecular Formula

C18H16N4O2
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C(=O)NC1=NC2=CC=CC=C2N1)N3CC4=CC=CC=C4C3=O
Chemical Name

(R)-N-(1H-benzo[d]imidazol-2-yl)-2-(1-oxoisoindolin-2-yl)propanamide

1. Henry KL, et al. Sci Signal. 2018 Jul 31;11(541). pii: eaam8216.

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